Anti-inflammatory agent 35

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anti-inflammatory agent 35 (化合物 5a27) 是一种口服有效的姜黄素类似物，具有抗炎活性。Anti-inflammatory agent 35 可阻断丝裂原活化蛋白激酶 (MAPK) 信号和 NF-kB 的核易位。Anti-inflammatory agent 35 还抑制黄中性粒细胞浸润和促炎细胞因子产生。Anti-inflammatory agent 35 在体内研究中显著减轻脂多糖 (LPS) 诱导的急性肺损伤 (ALI)。

Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.

Western Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:30 min; followed by incubation with 0.5 μg/mL LPS for another 30 min Result:Decreased the phosphorylation of p38 and ERK. And down-regulated IκB (inhibitor of NF-κB), inhibits the transcription of TNF-α, IL-6, IL-1β, ICAM-1.

Animal Model:ALI mouse model (C57BL/6 mice)Dosage:10 mg/kg Administration:Intraperitoneal injection, once daily for 1 week; 30 min later every dose, followed by 5 mg/kg LPS, intratracheal injection Result:Significantly normalized the wet/dry ratio of lungs.

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Others

Other Targets

Immunology/Inflammation related

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2293951-00-3

495.52

C27H29NO8

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 16.67 mg/mL (33.64 mM; 超声助溶 (<60°C)

COc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1OC(C)=O

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(-20℃)

With Ice Pack

≥ 2 years